Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53

Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the molecular mechanisms by which UVR drives melanomagenesis remain unclear(1,2). The most common somatic mutation in melanoma is a V600E substitution in BRAF, which is an early event(3). To investigate how UVR accele...

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Main Authors: Viros, Amaya, Sanchez-Laorden, Berta, Pedersen, Malin, Furney, Simon J., Rae, Joel, Hogan, Kate, Ejiama, Sarah, Girotti, Maria Romina, Cook, Martin, Dhomen, Nathalie, Marais, Richard
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112218/
https://ncbi.nlm.nih.gov/pubmed/24919155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13298
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