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Metformin accelerates the growth of BRAF(V600E)-driven melanoma by upregulating VEGF-A
The anti-diabetic drug metformin has anti-tumor activity in a variety of cancers because it blocks cell growth by inhibiting TORC1. Here we show that melanoma cells that are driven by oncogenic BRAF are resistant to the growth-inhibitory effects of metformin because RSK sustains TORC1 activity even...
Bewaard in:
| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364710/ https://ncbi.nlm.nih.gov/pubmed/22576211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0280 |
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