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Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

BACKGROUND: Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with dabrafenib, a selective BRAF inhibitor, and trametinib, a selec...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Flaherty, Keith T., Infante, Jeffery R., Daud, Adil, Gonzalez, Rene, Kefford, Richard F., Sosman, Jeffrey, Hamid, Omid, Schuchter, Lynn, Cebon, Jonathan, Ibrahim, Nageatte, Kudchadkar, Ragini, Burris, Howard A., Falchook, Gerald, Algazi, Alain, Lewis, Karl, Long, Georgina V., Puzanov, Igor, Lebowitz, Peter, Singh, Ajay, Little, Shonda, Sun, Peng, Allred, Alicia, Ouellet, Daniele, Kim, Kevin B., Patel, Kiran, Weber, Jeffrey
التنسيق: Artigo
اللغة:Inglês
منشور في: 2012
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549295/
https://ncbi.nlm.nih.gov/pubmed/23020132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1210093
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