The role of BRAF V600 mutation in melanoma

BRAF is a serine/threonine protein kinase activating the MAP kinase/ERK-signaling pathway. About 50 % of melanomas harbors activating BRAF mutations (over 90 % V600E). BRAFV600E has been implicated in different mechanisms underlying melanomagenesis, most of which due to the deregulated activation of...

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Detalhes bibliográficos
Main Authors: Ascierto, Paolo A, Kirkwood, John M, Grob, Jean-Jacques, Simeone, Ester, Grimaldi, Antonio M, Maio, Michele, Palmieri, Giuseppe, Testori, Alessandro, Marincola, Francesco M, Mozzillo, Nicola
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Commentary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391993/
https://ncbi.nlm.nih.gov/pubmed/22554099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-85
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