Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression

Por Vennin, Claire, Herrmann, David, Lucas, Morghan C., Timpson, Paul
Publicado no F1000Res (2016)

Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells

Por Dawson, John C., Timpson, Paul, Kalna, Gabriela, Machesky, Laura M.
Publicado em 2011

There are four dynamically and functionally distinct populations of E-cadherin in cell junctions

Por Erami, Zahra, Timpson, Paul, Yao, Wu, Zaidel-Bar, Ronen, Anderson, Kurt I.
Publicado no Biol Open (2015)

A role for the actin cytoskeleton in cell death and aging in yeast

Por Gourlay, Campbell W., Carpp, Lindsay N., Timpson, Paul, Winder, Steven J., Ayscough, Kathryn R.
Publicado em 2004

Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in 3D

Por Spence, Heather J., Timpson, Paul, Tang, Hao Ran, Insall, Robert H., Machesky, Laura M.
Publicado em 2012

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

Por Timpson, Paul, Serrels, Alan, Canel, Marta, Frame, Margaret C, Brunton, Valerie G, Anderson, Kurt I
Publicado em 2009

Inhibition of autophagy impairs tumor cell invasion in an organotypic model

Por Macintosh, Robin L., Timpson, Paul, Thorburn, Jacqueline, Anderson, Kurt I., Thorburn, Andrew, Ryan, Kevin M.
Publicado em 2012

Quantitative in vivo imaging of the effects of inhibiting integrin signalling via Src and FAK on cancer cell movement; effects on E-cadherin dynamics

Por Canel, Marta, Serrels, Alan, Miller, Derek, Timpson, Paul, Serrels, Bryan, Frame, Margaret C., Brunton, Valerie G.
Publicado em 2010

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

Por Marei, Hadir, Carpy, Alejandro, Woroniuk, Anna, Vennin, Claire, White, Gavin, Timpson, Paul, Macek, Boris, Malliri, Angeliki
Publicado no Nat Commun (2016)

The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking

Por Hoque, Monira, Rentero, Carles, Conway, James R, Murray, Rachael Z, Timpson, Paul, Enrich, Carlos, Grewal, Thomas
Publicado no Cell Adh Migr (2015)

Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context

Por Timpson, Paul, Mcghee, Ewan J., Erami, Zahra, Nobis, Max, Quinn, Jean A., Edward, Mike, Anderson, Kurt I.
Publicado em 2011

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

Por Chin, Venessa T., Nagrial, Adnan M., Chou, Angela, Biankin, Andrew V., Gill, Anthony J., Timpson, Paul, Pajic, Marina
Publicado no Expert Rev Mol Med (2015)

Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging

Por Nobis, Max, McGhee, Ewan J, Herrmann, David, Magenau, Astrid, Morton, Jennifer P, Anderson, Kurt I, Timpson, Paul
Publicado no Cell Adh Migr (2014)

The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment

Por Pajic, Marina, Herrmann, David, Vennin, Claire, Conway, James RW, Chin, Venessa T, Johnsson, Anna-Karin E, Welch, Heidi CE, Timpson, Paul
Publicado no Small GTPases (2015)

Protein Kinase Cδ and Calmodulin Regulate Epidermal Growth Factor Receptor Recycling from Early Endosomes through Arp2/3 Complex and Cortactin

Por Lladó, Anna, Timpson, Paul, Vilà de Muga, Sandra, Moretó, Jemina, Pol, Albert, Grewal, Thomas, Daly, Roger J., Enrich, Carlos, Tebar, Francesc
Publicado em 2008

Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

Por Isherwood, Beverley, Timpson, Paul, McGhee, Ewan J, Anderson, Kurt I, Canel, Marta, Serrels, Alan, Brunton, Valerie G, Carragher, Neil O
Publicado em 2011

Recruitment Kinetics of Tropomyosin Tpm3.1 to Actin Filament Bundles in the Cytoskeleton Is Independent of Actin Filament Kinetics

Por Appaduray, Mark A., Masedunskas, Andrius, Bryce, Nicole S., Lucas, Christine A., Warren, Sean C., Timpson, Paul, Stear, Jeffrey H., Gunning, Peter W., Hardeman, Edna C.
Publicado no PLoS One (2016)

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

Por McGhee, Ewan J, Morton, Jennifer P, Von Kriegsheim, Alex, Schwarz, Juliane P, Karim, Saadia A, Carragher, Neil O, Sansom, Owen J, Anderson, Kurt I, Timpson, Paul
Publicado em 2011

Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion

Por Vlahov, Nikola, Scrace, Simon, Soto, Manuel Sarmiento, Grawenda, Anna M., Bradley, Leanne, Pankova, Daniela, Papaspyropoulos, Angelos, Yee, Karen S., Buffa, Francesca, Goding, Colin R., Timpson, Paul, Sibson, Nicola, O’Neill, Eric
Publicado no Curr Biol (2015)

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

Por Brummer, Tilman, Larance, Mark, Abreu, Maria Teresa Herrera, Lyons, Ruth J, Timpson, Paul, Emmerich, Christoph H, Fleuren, Emmy D G, Lehrbach, Gillian M, Schramek, Daniel, Guilhaus, Michael, James, David E, Daly, Roger J
Publicado em 2008