GEFs: Dual regulation of Rac1 signaling

Por Marei, Hadir, Malliri, Angeliki
Publicado no Small GTPases (2016)

Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms

Por Marei, Hadir, Malliri, Angeliki
Publicado no Small GTPases (2016)

Centrosome separation; a careful balancing act

Por Whalley, Helen J, Malliri, Angeliki
Publicado no Cell Cycle (2015)

Deregulation of Rho GTPases in cancer

Por Porter, Andrew P., Papaioannou, Alexandra, Malliri, Angeliki
Publicado no Small GTPases (2016)

Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors

Por Marei, Hadir, Carpy, Alejandro, Macek, Boris, Malliri, Angeliki
Publicado no Cell Cycle (2016)

The diverse roles of Rac signaling in tumorigenesis

Por Mack, Natalie A, Whalley, Helen J, Castillo-Lluva, Sonia, Malliri, Angeliki
Publicado em 2011

The interaction between CASK and the tumour suppressor Dlg1 regulates mitotic spindle orientation in mammalian epithelia

Por Porter, Andrew P., White, Gavin R. M., Mack, Natalie A., Malliri, Angeliki
Publicado no J Cell Sci (2019)

The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly

Por Rooney, Claire, White, Gavin, Nazgiewicz, Alicja, Woodcock, Simon A, Anderson, Kurt I, Ballestrem, Christoph, Malliri, Angeliki
Publicado em 2010

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

Por Marei, Hadir, Carpy, Alejandro, Woroniuk, Anna, Vennin, Claire, White, Gavin, Timpson, Paul, Macek, Boris, Malliri, Angeliki
Publicado no Nat Commun (2016)

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation

Por Whalley, Helen J., Porter, Andrew P., Diamantopoulou, Zoi, White, Gavin R. M., Castañeda-Saucedo, Eduardo, Malliri, Angeliki
Publicado no Nat Commun (2015)

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels

Por Porter, Andrew P., Reed, Hannah, White, Gavin R. M., Ogg, Erinn-Lee, Whalley, Helen J., Malliri, Angeliki
Publicado no J Cell Sci (2021)

The Transcription Factor AP-1 Is Required for EGF-induced Activation of Rho-like GTPases, Cytoskeletal Rearrangements, Motility, and In Vitro Invasion of A431 Cells

Por Malliri, Angeliki, Symons, Marc, Hennigan, Robert F., Hurlstone, Adam F.L., Lamb, Richard F., Wheeler, Tricia, Ozanne, Bradford W.
Publicado em 1998

SUMOylation of the GTPase Rac1 is required for optimal cell migration

Por Castillo-Lluva, Sonia, Tatham, Michael H., Jones, Richard C., Jaffray, Ellis G., Edmondson, Ricky D., Hay, Ronald T., Malliri, Angeliki
Publicado em 2010

Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression

Por Woodcock, Simon A., Rushton, Helen J., Castañeda-Saucedo, Eduardo, Myant, Kevin, White, Gavin R.M., Blyth, Karen, Sansom, Owen J., Malliri, Angeliki
Publicado em 2010

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

Por Vaughan, Lynsey, Tan, Chong-Teik, Chapman, Anna, Nonaka, Daisuke, Mack, Natalie A., Smith, Duncan, Booton, Richard, Hurlstone, Adam F.L., Malliri, Angeliki
Publicado no Cell Rep (2014)

β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity

Por Mack, Natalie A., Porter, Andrew P., Whalley, Helen J., Schwarz, Juliane P., Jones, Richard C., Syed, Azharuddin Sajid, Bjartell, Anders, Anderson, Kurt I., Malliri, Angeliki
Publicado em 2012

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap

Por Woroniuk, Anna, Porter, Andrew, White, Gavin, Newman, Daniel T., Diamantopoulou, Zoi, Waring, Thomas, Rooney, Claire, Strathdee, Douglas, Marston, Daniel J., Hahn, Klaus M., Sansom, Owen J., Zech, Tobias, Malliri, Angeliki
Publicado no Nat Commun (2018)

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

Por Daugaard, Mads, Nitsch, Roberto, Razaghi, Babak, McDonald, Lindsay, Jarrar, Ameer, Torrino, Stéphanie, Castillo-Lluva, Sonia, Rotblat, Barak, Li, Liheng, Malliri, Angeliki, Lemichez, Emmanuel, Mettouchi, Amel, Berman, Jason N., Penninger, Josef M., Sorensen, Poul H.
Publicado em 2013

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

Por Diamantopoulou, Zoi, White, Gavin, Fadlullah, Muhammad Z.H., Dreger, Marcel, Pickering, Karen, Maltas, Joe, Ashton, Garry, MacLeod, Ruth, Baillie, George S., Kouskoff, Valerie, Lacaud, Georges, Murray, Graeme I., Sansom, Owen J., Hurlstone, Adam F.L., Malliri, Angeliki
Publicado no Cancer Cell (2017)

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

Por Myant, Kevin B, Cammareri, Patrizia, Hodder, Michael C, Wills, Jimi, Von Kriegsheim, Alex, Győrffy, Balázs, Rashid, Mamun, Polo, Simona, Maspero, Elena, Vaughan, Lynsey, Gurung, Basanta, Barry, Evan, Malliri, Angeliki, Camargo, Fernando, Adams, David J, Iavarone, Antonio, Lasorella, Anna, Sansom, Owen J
Publicado no EMBO Mol Med (2016)