HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

Cancer genome sequencing projects have identified hundreds of genetic alterations, often at low frequencies, raising questions as to their functional relevance. One exemplar gene is HUWE1, which has been found to be mutated in numerous studies. However, due to the large size of this gene and a lack...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Myant, Kevin B, Cammareri, Patrizia, Hodder, Michael C, Wills, Jimi, Von Kriegsheim, Alex, Győrffy, Balázs, Rashid, Mamun, Polo, Simona, Maspero, Elena, Vaughan, Lynsey, Gurung, Basanta, Barry, Evan, Malliri, Angeliki, Camargo, Fernando, Adams, David J, Iavarone, Antonio, Lasorella, Anna, Sansom, Owen J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286368/
https://ncbi.nlm.nih.gov/pubmed/28003334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606684
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