HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor formation. Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression. In MDCKII cells in response to HGF, H...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Vaughan, Lynsey, Tan, Chong-Teik, Chapman, Anna, Nonaka, Daisuke, Mack, Natalie A., Smith, Duncan, Booton, Richard, Hurlstone, Adam F.L., Malliri, Angeliki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542307/
https://ncbi.nlm.nih.gov/pubmed/25543140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.12.012
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