β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity

Although Rac and its activator Tiam1 are known to stimulate cell-cell adhesion, the mechanisms regulating their activity in cell-cell junction formation are poorly understood. Here, we identify β2-syntrophin as a Tiam1 interactor required for optimal cell-cell adhesion. We show that during tight jun...

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Hauptverfasser: Mack, Natalie A., Porter, Andrew P., Whalley, Helen J., Schwarz, Juliane P., Jones, Richard C., Syed, Azharuddin Sajid, Bjartell, Anders, Anderson, Kurt I., Malliri, Angeliki
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498067/
https://ncbi.nlm.nih.gov/pubmed/23103911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2608
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