The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly

Focal adhesion (FA) disassembly required for optimal cell migration is mediated by microtubules (MTs); targeting of FAs by MTs coincides with their disassembly. Regrowth of MTs, induced by removal of the MT destabilizer nocodazole, activates the Rho-like GTPase Rac, concomitant with FA disassembly....

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Main Authors: Rooney, Claire, White, Gavin, Nazgiewicz, Alicja, Woodcock, Simon A, Anderson, Kurt I, Ballestrem, Christoph, Malliri, Angeliki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Scientific Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854589/
https://ncbi.nlm.nih.gov/pubmed/20224579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.10
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