Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression

Centrosome separation, critical for bipolar spindle formation and subsequent chromosome segregation during mitosis, occurs via distinct prophase and prometaphase pathways [1–3]. Kinesin-5 (Eg5), a microtubule (MT) motor, pushes centrosomes apart during bipolar spindle assembly [4]; its suppression r...

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Main Authors: Woodcock, Simon A., Rushton, Helen J., Castañeda-Saucedo, Eduardo, Myant, Kevin, White, Gavin R.M., Blyth, Karen, Sansom, Owen J., Malliri, Angeliki
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2010
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989435/
https://ncbi.nlm.nih.gov/pubmed/20346677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.02.033
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