Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation

Centrosome separation is critical for bipolar spindle formation and the accurate segregation of chromosomes during mammalian cell mitosis. Kinesin-5 (Eg5) is a microtubule motor essential for centrosome separation, and Tiam1 and its substrate Rac antagonize Eg5-dependent centrosome separation in ear...

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發表在:Nat Commun
Main Authors: Whalley, Helen J., Porter, Andrew P., Diamantopoulou, Zoi, White, Gavin R. M., Castañeda-Saucedo, Eduardo, Malliri, Angeliki
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490568/
https://ncbi.nlm.nih.gov/pubmed/26078008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8437
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