Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression

Centrosome separation, critical for bipolar spindle formation and subsequent chromosome segregation during mitosis, occurs via distinct prophase and prometaphase pathways [1–3]. Kinesin-5 (Eg5), a microtubule (MT) motor, pushes centrosomes apart during bipolar spindle assembly [4]; its suppression r...

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Hlavní autoři: Woodcock, Simon A., Rushton, Helen J., Castañeda-Saucedo, Eduardo, Myant, Kevin, White, Gavin R.M., Blyth, Karen, Sansom, Owen J., Malliri, Angeliki
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989435/
https://ncbi.nlm.nih.gov/pubmed/20346677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.02.033
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