Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression

Centrosome separation, critical for bipolar spindle formation and subsequent chromosome segregation during mitosis, occurs via distinct prophase and prometaphase pathways [1–3]. Kinesin-5 (Eg5), a microtubule (MT) motor, pushes centrosomes apart during bipolar spindle assembly [4]; its suppression r...

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Hauptverfasser: Woodcock, Simon A., Rushton, Helen J., Castañeda-Saucedo, Eduardo, Myant, Kevin, White, Gavin R.M., Blyth, Karen, Sansom, Owen J., Malliri, Angeliki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2010
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989435/
https://ncbi.nlm.nih.gov/pubmed/20346677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.02.033
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