Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumour progression. We show that LOX regulates EGFR by...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Tang, HaoRan, Leung, Leo, Saturno, Grazia, Viros, Amaya, Smith, Duncan, Di Leva, Gianpiero, Morrison, Eamonn, Niculescu-Duvaz, Dan, Lopes, Filipa, Johnson, Louise, Dhomen, Nathalie, Springer, Caroline, Marais, Richard
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399287/
https://ncbi.nlm.nih.gov/pubmed/28416796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14909
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