Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent BRAF binding to CRAF, CRAF activation, and MEK–ERK signaling. This does not occur when oncogenic BRAF is inhibited, demonstrati...

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Detalhes bibliográficos
Main Authors: Heidorn, Sonja J., Milagre, Carla, Whittaker, Steven, Nourry, Arnaud, Niculescu-Duvas, Ion, Dhomen, Nathalie, Hussain, Jahan, Reis-Filho, Jorge S., Springer, Caroline J., Pritchard, Catrin, Marais, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872605/
https://ncbi.nlm.nih.gov/pubmed/20141835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.12.040
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