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CRAF Autophosphorylation of Serine 621 Is Required to Prevent Its Proteasome-Mediated Degradation
The CRAF protein kinase regulates proliferative, differentiation, and survival signals from activated RAS proteins to downstream effectors, most often by inducing MEK/ERK activation. A well-established model of CRAF regulation involves RAS-mediated translocation of CRAF to the plasma membrane, where...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2640467/ https://ncbi.nlm.nih.gov/pubmed/18922468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.08.026 |
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