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CRAF Autophosphorylation of Serine 621 Is Required to Prevent Its Proteasome-Mediated Degradation

The CRAF protein kinase regulates proliferative, differentiation, and survival signals from activated RAS proteins to downstream effectors, most often by inducing MEK/ERK activation. A well-established model of CRAF regulation involves RAS-mediated translocation of CRAF to the plasma membrane, where...

詳細記述

保存先:
書誌詳細
主要な著者: Noble, Catherine, Mercer, Kathryn, Hussain, Jahan, Carragher, Linda, Giblett, Susan, Hayward, Robert, Patterson, Cam, Marais, Richard, Pritchard, Catrin A.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640467/
https://ncbi.nlm.nih.gov/pubmed/18922468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.08.026
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