Expression of Endogenous Oncogenic (V600E)B-raf Induces Proliferation and Developmental Defects in Mice and Transformation of Primary Fibroblasts

Mutations of the human B-RAF gene are detected in ∼8% of cancer samples, primarily in cutaneous melanomas (70%). The most common mutation (90%) is a valine-to-glutamic acid mutation at residue 600 (V600E; formerly V599E according to previous nomenclature). Using a Cre/Lox approach, we have generated...

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Bibliografiske detaljer
Main Authors: Mercer, Kathryn, Giblett, Susan, Green, Stuart, Lloyd, David, Dias, Silvy DaRocha, Plumb, Mark, Marais, Richard, Pritchard, Catrin
Format: Artigo
Sprog:Inglês
Udgivet: 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640458/
https://ncbi.nlm.nih.gov/pubmed/16357158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-05-2211
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