MEK kinase activity is not necessary for Raf-1 function

Raf-1 protein kinase has been identified as an integral component of the Ras/Raf/MEK/ERK signalling pathway in mammals. Activation of Raf-1 is achieved by Ras.GTP binding and other events at the plasma membrane including tyrosine phosphorylation at residues 340/341. We have used gene targeting to ge...

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Bibliografiske detaljer
Main Authors: Hüser, Martin, Luckett, Jeni, Chiloeches, Antonio, Mercer, Kathryn, Iwobi, Mabel, Giblett, Susan, Sun, Xiao-Ming, Brown, Jane, Marais, Richard, Pritchard, Catrin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC125235/
https://ncbi.nlm.nih.gov/pubmed/11296227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.8.1940
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