MEK kinase activity is not necessary for Raf-1 function

Raf-1 protein kinase has been identified as an integral component of the Ras/Raf/MEK/ERK signalling pathway in mammals. Activation of Raf-1 is achieved by Ras.GTP binding and other events at the plasma membrane including tyrosine phosphorylation at residues 340/341. We have used gene targeting to ge...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Hüser, Martin, Luckett, Jeni, Chiloeches, Antonio, Mercer, Kathryn, Iwobi, Mabel, Giblett, Susan, Sun, Xiao-Ming, Brown, Jane, Marais, Richard, Pritchard, Catrin
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2001
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11296227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.8.1940
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