Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals

Two Ras effector pathways leading to the activation of Raf-1 and phosphatidylinositol 3-kinase (PI3K) have been implicated in the survival signaling by the interleukin 3 (IL-3) receptor. Analysis of apoptosis suppression by Raf-1 demonstrated the requirement for mitochondrial translocation of the ki...

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Detalhes bibliográficos
Main Authors: von Gise, Alexander, Lorenz, Petra, Wellbrock, Claudia, Hemmings, Brian, Berberich-Siebelt, Friederike, Rapp, Ulf R., Troppmair, Jakob
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86866/
https://ncbi.nlm.nih.gov/pubmed/11259582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.7.2324-2336.2001
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