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Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

NF-κB is regulated by inhibitor proteins (IκBs), which retain NF-κB in the cytoplasm. Signal-induced phosphorylation by the IκB-kinase complex containing the IκB-kinases 1 and 2 (IKK-1/2 or IKK-α/β) and subsequent degradation of the IκB proteins are prerequisites for NF-κB activation. Many signals i...

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Hlavní autoři: Baumann, Bernd, Weber, Christoph K., Troppmair, Jakob, Whiteside, Simon, Israel, Alain, Rapp, Ulf R., Wirth, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC18281/
https://ncbi.nlm.nih.gov/pubmed/10758165
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