Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

NF-κB is regulated by inhibitor proteins (IκBs), which retain NF-κB in the cytoplasm. Signal-induced phosphorylation by the IκB-kinase complex containing the IκB-kinases 1 and 2 (IKK-1/2 or IKK-α/β) and subsequent degradation of the IκB proteins are prerequisites for NF-κB activation. Many signals i...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Baumann, Bernd, Weber, Christoph K., Troppmair, Jakob, Whiteside, Simon, Israel, Alain, Rapp, Ulf R., Wirth, Thomas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10758165/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.080583397
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