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BRAF inactivation drives aneuploidy by deregulating CRAF

Aspartate 594 is the third most common BRAF residue mutated in human cancer. Mutants of this residue are kinase inactive and the mechanism(s) by which they contribute to cancer has remained perplexing. Using a conditional knock-in mouse model, we show that the (D594A)Braf mutant does not drive tumor...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kamata, Tamihiro, Hussain, Jahan, Giblett, Susan, Hayward, Robert, Marais, Richard, Pritchard, Catrin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975377/
https://ncbi.nlm.nih.gov/pubmed/20978199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0603
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