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BRAF inactivation drives aneuploidy by deregulating CRAF
Aspartate 594 is the third most common BRAF residue mutated in human cancer. Mutants of this residue are kinase inactive and the mechanism(s) by which they contribute to cancer has remained perplexing. Using a conditional knock-in mouse model, we show that the (D594A)Braf mutant does not drive tumor...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975377/ https://ncbi.nlm.nih.gov/pubmed/20978199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0603 |
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