Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes

NRAS mutations are common in human melanoma. To produce a mouse model of NRAS-driven melanoma, we expressed oncogenic NRAS (NRAS(G12D)) in mouse melanocytes. When NRAS(G12D) was expressed in the melanocytes of developing embryos, it induced melanocyte proliferation and congenital melanocytic lesions...

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Autores principales: Pedersen, Malin, Küsters-Vandevelde, Heidi V.N., Viros, Amaya, Groenen, Patricia J.T.A., Sanchez-Laorden, Berta, Gilhuis, Jacobus H., van Engen- van Grunsven, Ilse A., Renier, Willy, Schieving, Jolanda, Niculescu-Duvaz, Ion, Springer, Caroline J., Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A.M., Marais, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999382/
https://ncbi.nlm.nih.gov/pubmed/23303902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0464
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