Bioreactors get personal

por Somerville, Robert P.T., Dudley, Mark E.
Publicado em 2012

From Lipoproteins to Chondrocytes: A Brief Summary of the European Medicines Agency's Regulatory Guidelines for Advanced Therapy Medicinal Products

por Kassim, Sadik H., Somerville, Robert P.T.
Publicado em 2013

Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation

por Enomoto, Hiroyuki, Nelson, Courtney M., Somerville, Robert P. T., Mielke, Katrina, Dixon, Laura J., Powell, Kimerly, Apte, Suneel S.
Publicado em 2010

ADAMTS9 Is a Cell-Autonomously Acting, Anti-Angiogenic Metalloprotease Expressed by Microvascular Endothelial Cells

por Koo, Bon-Hun, Coe, David M., Dixon, Laura J., Somerville, Robert P.T., Nelson, Courtney M., Wang, Lauren W., Young, Mary Elizabeth, Lindner, Daniel J., Apte, Suneel S.
Publicado em 2010

Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion

por Benz, Brian A., Nandadasa, Sumeda, Takeuchi, Megumi, Grady, Richard C., Takeuchi, Hideyuki, LoPilato, Rachel K., Kakuda, Shinako, Somerville, Robert P.T., Apte, Suneel S., Haltiwanger, Robert S., Holdener, Bernadette C.
Publicado no Dev Biol (2016)

Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy

por Kochenderfer, James N., Somerville, Robert P.T., Lu, Tangying, Yang, James C., Sherry, Richard M., Feldman, Steven A., McIntyre, Lori, Bot, Adrian, Rossi, John, Lam, Norris, Rosenberg, Steven A.
Publicado no Mol Ther (2017)

Immunogenicity of somatic mutations in human gastrointestinal cancers

por Tran, Eric, Ahmadzadeh, Mojgan, Lu, Yong-Chen, Gros, Alena, Turcotte, Simon, Robbins, Paul F., Gartner, Jared J., Zheng, Zhili, Li, Yong F., Ray, Satyajit, Wunderlich, John R., Somerville, Robert P., Rosenberg, Steven A.
Publicado no Science (2015)

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

por Tran, Eric, Turcotte, Simon, Gros, Alena, Robbins, Paul F., Lu, Yong-Chen, Dudley, Mark E., Wunderlich, John R., Somerville, Robert P., Hogan, Katherine, Hinrichs, Christian S., Parkhurst, Maria R., Yang, James C., Rosenberg, Steven A.
Publicado no Science (2014)

A phase II study of tumor-infiltrating lymphocyte therapy for human papillomavirus-associated epithelial cancers

por Stevanović, Sanja, Helman, Sarah R., Wunderlich, John R., Langhan, Michelle M., Doran, Stacey L., Kwong, Mei Li M., Somerville, Robert P., Klebanoff, Christopher A., Kammula, Udai S., Sherry, Richard M., Yang, James C., Rosenberg, Steven A., Hinrichs, Christian S.
Publicado no Clin Cancer Res (2018)

T-cell responses to TP53 “hotspot” mutations and unique neoantigens expressed by human ovarian cancers

por Deniger, Drew C., Pasetto, Anna, Robbins, Paul F., Gartner, Jared J., Prickett, Todd D., Paria, Biman C., Malekzadeh, Parisa, Jia, Li, Yossef, Rami, Langhan, Michelle M., Wunderlich, John R., Danforth, David N., Somerville, Robert P.T., Rosenberg, Steven A.
Publicado no Clin Cancer Res (2018)

Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

por Malekzadeh, Parisa, Pasetto, Anna, Robbins, Paul F., Parkhurst, Maria R., Paria, Biman C., Jia, Li, Gartner, Jared J., Hill, Victoria, Yu, Zhiya, Restifo, Nicholas P., Sachs, Abraham, Tran, Eric, Lo, Winifred, Somerville, Robert P.T., Rosenberg, Steven A., Deniger, Drew C.
Publicado no J Clin Invest (2019)

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

por Zacharakis, Nikolaos, Chinnasamy, Harshini, Black, Mary, Xu, Hui, Lu, Yong-Chen, Zheng, Zhili, Pasetto, Anna, Langhan, Michelle, Shelton, Thomas, Prickett, Todd, Gartner, Jared, Jia, Li, Trebska-McGowan, Katarzyna, Somerville, Robert P., Robbins, Paul F., Rosenberg, Steven A., Goff, Stephanie L., Feldman, Steven A.
Publicado no Nat Med (2018)

Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer

por Assadipour, Yasmine, Zacharakis, Nikolaos, Crystal, Jessica S., Prickett, Todd D., Gartner, Jared J., Somerville, Robert P.T., Xu, Hui, Black, Mary A., Jia, Li, Chinnasamy, Harshini, Kriley, Isaac, Lu, Lily, Wunderlich, John R., Zheng, Zhili, Lu, Yong-Chen, Robbins, Paul F., Rosenberg, Steven A., Goff, Stephanie L., Feldman, Steven A.
Publicado no Clin Cancer Res (2017)

Randomized Selection Design Trial Evaluating CD8(+)-Enriched Versus Unselected Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy for Patients With Melanoma

por Dudley, Mark E., Gross, Colin A., Somerville, Robert P.T., Hong, Young, Schaub, Nicholas P., Rosati, Shannon F., White, Donald E., Nathan, Debbie, Restifo, Nicholas P., Steinberg, Seth M., Wunderlich, John R., Kammula, Udai S., Sherry, Richard M., Yang, James C., Phan, Giao Q., Hughes, Marybeth S., Laurencot, Carolyn M., Rosenberg, Steven A.
Publicado em 2013

Treatment of metastatic uveal melanoma with adoptive transfer of tumor infiltrating lymphocytes: a single-center phase 2 study

por Chandran, Smita S., Somerville, Robert P.T., Yang, James C., Sherry, Richard M., Klebanoff, Christopher A., Goff, Stephanie L., Wunderlich, John R., Danforth, David N., Zlott, Daniel, Paria, Biman C., Sabesan, Arvind C., Srivastava, Abhishek K., Xi, Liqiang, Pham, Trinh H., Raffeld, Mark, White, Donald E., Toomey, Mary Ann, Rosenberg, Steven A., Kammula, Udai S.
Publicado no Lancet Oncol (2017)

Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens

por Malekzadeh, Parisa, Yossef, Rami, Cafri, Gal, Paria, Biman C., Lowery, Frank J., Jafferji, Mohammad, Good, Meghan L., Sachs, Abraham, Copeland, Amy R., Kim, Sanghyun P., Kivitz, Scott, Parkhurst, Maria R., Robbins, Paul F., Ray, Satyajit, Xi, Liqiang, Raffeld, Mark, Yu, Zhiya, Restifo, Nicholas P., Somerville, Robert P.T., Rosenberg, Steven A., Deniger, Drew C.
Publicado no Clin Cancer Res (2020)

Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels

por Kochenderfer, James N., Somerville, Robert P.T., Lu, Tangying, Shi, Victoria, Bot, Adrian, Rossi, John, Xue, Allen, Goff, Stephanie L., Yang, James C., Sherry, Richard M., Klebanoff, Christopher A., Kammula, Udai S., Sherman, Marika, Perez, Arianne, Yuan, Constance M., Feldman, Tatyana, Friedberg, Jonathan W., Roschewski, Mark J., Feldman, Steven A., McIntyre, Lori, Toomey, Mary Ann, Rosenberg, Steven A.
Publicado no J Clin Oncol (2017)

Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantati...

por Brudno, Jennifer N., Somerville, Robert P.T., Shi, Victoria, Rose, Jeremy J., Halverson, David C., Fowler, Daniel H., Gea-Banacloche, Juan C., Pavletic, Steven Z., Hickstein, Dennis D., Lu, Tangying L., Feldman, Steven A., Iwamoto, Alexander T., Kurlander, Roger, Maric, Irina, Goy, Andre, Hansen, Brenna G., Wilder, Jennifer S., Blacklock-Schuver, Bazetta, Hakim, Frances T., Rosenberg, Steven A., Gress, Ronald E., Kochenderfer, James N.
Publicado no J Clin Oncol (2016)

Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen R...

por Kochenderfer, James N., Dudley, Mark E., Kassim, Sadik H., Somerville, Robert P.T., Carpenter, Robert O., Stetler-Stevenson, Maryalice, Yang, James C., Phan, Giao Q., Hughes, Marybeth S., Sherry, Richard M., Raffeld, Mark, Feldman, Steven, Lu, Lily, Li, Yong F., Ngo, Lien T., Goy, Andre, Feldman, Tatyana, Spaner, David E., Wang, Michael L., Chen, Clara C., Kranick, Sarah M., Nath, Avindra, Nathan, Debbie-Ann N., Morton, Kathleen E., Toomey, Mary Ann, Rosenberg, Steven A.
Publicado no J Clin Oncol (2015)

Unique neoantigens arise from somatic mutations in patients with gastrointestinal cancers

por Parkhurst, Maria R., Robbins, Paul F., Tran, Eric, Prickett, Todd D., Gartner, Jared J., Jia, Li, Ivey, Gabriel, Li, Yong F., El-Gamil, Mona, Lalani, Almin, Crystal, Jessica S., Sachs, Abraham, Groh, Eric, Ray, Satyajit, Ngo, Lien T., Kivitz, Scott, Pasetto, Anna, Yossef, Rami, Lowery, Frank J., Goff, Stephanie L., Lo, Winifred, Cafri, Gal, Deniger, Drew C., Malekzadeh, Parisa, Ahmadzadeh, Mojgan, Wunderlich, John R., Somerville, Robert P.T., Rosenberg, Steven A.
Publicado no Cancer Discov (2019)