Immunogenicity of somatic mutations in human gastrointestinal cancers

It is unknown whether the human immune system frequently mounts a T cell response against mutations expressed by common epithelial cancers. Using a next-generation sequencing approach combined with high-throughput immunologic screening, we demonstrated that tumor-infiltrating lymphocytes (TILs) from...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Tran, Eric, Ahmadzadeh, Mojgan, Lu, Yong-Chen, Gros, Alena, Turcotte, Simon, Robbins, Paul F., Gartner, Jared J., Zheng, Zhili, Li, Yong F., Ray, Satyajit, Wunderlich, John R., Somerville, Robert P., Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7445892/
https://ncbi.nlm.nih.gov/pubmed/26516200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad1253
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