Unique neoantigens arise from somatic mutations in patients with gastrointestinal cancers

Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers. This raises the question of whether patients with these common cancers harbor T lymphocytes that recognize mutant proteins expressed by autol...

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Vydáno v:Cancer Discov
Hlavní autoři: Parkhurst, Maria R., Robbins, Paul F., Tran, Eric, Prickett, Todd D., Gartner, Jared J., Jia, Li, Ivey, Gabriel, Li, Yong F., El-Gamil, Mona, Lalani, Almin, Crystal, Jessica S., Sachs, Abraham, Groh, Eric, Ray, Satyajit, Ngo, Lien T., Kivitz, Scott, Pasetto, Anna, Yossef, Rami, Lowery, Frank J., Goff, Stephanie L., Lo, Winifred, Cafri, Gal, Deniger, Drew C., Malekzadeh, Parisa, Ahmadzadeh, Mojgan, Wunderlich, John R., Somerville, Robert P.T., Rosenberg, Steven A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138461/
https://ncbi.nlm.nih.gov/pubmed/31164343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1494
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