Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy

Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) targeting neoantigens can mediate tumor regression in selected patients with metastatic epithelial cancer. However, effectively identifying and harnessing neoantigen-reactive T cells for patient treatment remains a challenge and i...

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Udgivet i:JCI Insight
Main Authors: Yossef, Rami, Tran, Eric, Deniger, Drew C., Gros, Alena, Pasetto, Anna, Parkhurst, Maria R., Gartner, Jared J., Prickett, Todd D., Cafri, Gal, Robbins, Paul F., Rosenberg, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237474/
https://ncbi.nlm.nih.gov/pubmed/30282837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122467
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