Tumor- and neoantigen-reactive T-cell receptors can be identified based on their frequency in fresh tumor

Adoptive transfer of T cells with engineered T-cell receptor (TCR) genes that target tumor-specific antigens can mediate cancer regression. Accumulating evidence suggests that the clinical success of many immunotherapies is mediated by T-cells targeting mutated neoantigens unique to the patient. We...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Immunol Res
Auteurs principaux: Pasetto, Anna, Gros, Alena, Robbins, Paul F, Deniger, Drew C, Prickett, Todd D, Matus-Nicodemos, Rodrigo, Douek, Daniel C, Howie, Bryan, Robins, Harlan, Parkhurst, Maria R, Gartner, Jared, Trebska-McGowan, Katarzyna, Crystal, Jessica S, Rosenberg, Steven A
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010958/
https://ncbi.nlm.nih.gov/pubmed/27354337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0001
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires