Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression

PURPOSE: The adoptive transfer of lymphocytes genetically modified to express tumor reactive T-cell receptors (TCR) can mediate tumor regression. Some tumor-infiltrating lymphocytes (TIL) recognize somatic mutations expressed only in the patient’s tumors, and evidence suggests that clinically effect...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Parkhurst, Maria, Gros, Alena, Pasetto, Anna, Prickett, Todd, Crystal, Jessica S., Robbins, Paul, Rosenberg, Steven A.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453117/
https://ncbi.nlm.nih.gov/pubmed/27827318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2680
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