Tumor- and neoantigen-reactive T-cell receptors can be identified based on their frequency in fresh tumor

Adoptive transfer of T cells with engineered T-cell receptor (TCR) genes that target tumor-specific antigens can mediate cancer regression. Accumulating evidence suggests that the clinical success of many immunotherapies is mediated by T-cells targeting mutated neoantigens unique to the patient. We...

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Publicado en:Cancer Immunol Res
Autores principales: Pasetto, Anna, Gros, Alena, Robbins, Paul F, Deniger, Drew C, Prickett, Todd D, Matus-Nicodemos, Rodrigo, Douek, Daniel C, Howie, Bryan, Robins, Harlan, Parkhurst, Maria R, Gartner, Jared, Trebska-McGowan, Katarzyna, Crystal, Jessica S, Rosenberg, Steven A
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010958/
https://ncbi.nlm.nih.gov/pubmed/27354337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0001
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