Unique neoantigens arise from somatic mutations in patients with gastrointestinal cancers

Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers. This raises the question of whether patients with these common cancers harbor T lymphocytes that recognize mutant proteins expressed by autol...

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Bibliografski detalji
Izdano u:Cancer Discov
Glavni autori: Parkhurst, Maria R., Robbins, Paul F., Tran, Eric, Prickett, Todd D., Gartner, Jared J., Jia, Li, Ivey, Gabriel, Li, Yong F., El-Gamil, Mona, Lalani, Almin, Crystal, Jessica S., Sachs, Abraham, Groh, Eric, Ray, Satyajit, Ngo, Lien T., Kivitz, Scott, Pasetto, Anna, Yossef, Rami, Lowery, Frank J., Goff, Stephanie L., Lo, Winifred, Cafri, Gal, Deniger, Drew C., Malekzadeh, Parisa, Ahmadzadeh, Mojgan, Wunderlich, John R., Somerville, Robert P.T., Rosenberg, Steven A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138461/
https://ncbi.nlm.nih.gov/pubmed/31164343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1494
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