Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

Limited evidence exists that humans mount a mutation-specific T cell response to epithelial cancers. We used a whole-exomic-sequencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL) from a patient with metastatic cholangiocarcinoma contained CD4+ T helper 1 (T(H)1) cells rec...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Tran, Eric, Turcotte, Simon, Gros, Alena, Robbins, Paul F., Lu, Yong-Chen, Dudley, Mark E., Wunderlich, John R., Somerville, Robert P., Hogan, Katherine, Hinrichs, Christian S., Parkhurst, Maria R., Yang, James C., Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686185/
https://ncbi.nlm.nih.gov/pubmed/24812403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1251102
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