Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion

Protein O-fucosyltransferase 2 (POFUT2) adds O-linked fucose to Thrombospondin Type 1 Repeats (TSR) in 49 potential target proteins. Nearly half the POFUT2 targets belong to the A Disintegrin and Metalloprotease with ThromboSpondin type-1 motifs (ADAMTS) or ADAMTS-like family of proteins. Both the m...

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Udgivet i:Dev Biol
Main Authors: Benz, Brian A., Nandadasa, Sumeda, Takeuchi, Megumi, Grady, Richard C., Takeuchi, Hideyuki, LoPilato, Rachel K., Kakuda, Shinako, Somerville, Robert P.T., Apte, Suneel S., Haltiwanger, Robert S., Holdener, Bernadette C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572823/
https://ncbi.nlm.nih.gov/pubmed/27297885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2016.05.038
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