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O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function

Fucosylation of Epidermal Growth Factor-like (EGF) repeats by protein O-fucosyltransferase 1 (POFUT1 in vertebrates, OFUT1 in Drosophila) is pivotal for NOTCH function. In Drosophila OFUT1 also acts as chaperone for Notch independent from its enzymatic activity. NOTCH ligands are also substrates for...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Müller, Julia, Rana, Nadia A., Serth, Katrin, Kakuda, Shinako, Haltiwanger, Robert S., Gossler, Achim
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922938/
https://ncbi.nlm.nih.gov/pubmed/24533113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088571
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