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O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function

Fucosylation of Epidermal Growth Factor-like (EGF) repeats by protein O-fucosyltransferase 1 (POFUT1 in vertebrates, OFUT1 in Drosophila) is pivotal for NOTCH function. In Drosophila OFUT1 also acts as chaperone for Notch independent from its enzymatic activity. NOTCH ligands are also substrates for...

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Détails bibliographiques
Auteurs principaux: Müller, Julia, Rana, Nadia A., Serth, Katrin, Kakuda, Shinako, Haltiwanger, Robert S., Gossler, Achim
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922938/
https://ncbi.nlm.nih.gov/pubmed/24533113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088571
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