Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo

The Notch ligands Dll1 and Dll3 are coexpressed in the presomitic mesoderm of mouse embryos. Despite their coexpression, mutations in Dll1 and Dll3 cause strikingly different defects. To determine if there is any functional equivalence, we replaced Dll1 with Dll3 in mice. Dll3 does not compensate fo...

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Bibliografiska uppgifter
Huvudupphovsmän: Geffers, Insa, Serth, Katrin, Chapman, Gavin, Jaekel, Robert, Schuster-Gossler, Karin, Cordes, Ralf, Sparrow, Duncan B., Kremmer, Elisabeth, Dunwoodie, Sally L., Klein, Thomas, Gossler, Achim
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2007
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064846/
https://ncbi.nlm.nih.gov/pubmed/17664336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200702009
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