O-Fucosylation of DLL3 Is Required for Its Function during Somitogenesis

Delta-like 3 (DLL3) is a member of the DSL family of Notch ligands in amniotes. In contrast to DLL1 and DLL4, the other Delta-like proteins in the mouse, DLL3 does not bind in trans to Notch and does not activate the receptor, but shows cis-interaction and cis-inhibitory properties on Notch signalin...

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Bibliographic Details
Published in:PLoS One
Main Authors: Serth, Katrin, Schuster-Gossler, Karin, Kremmer, Elisabeth, Hansen, Birte, Marohn-Köhn, Britta, Gossler, Achim
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391858/
https://ncbi.nlm.nih.gov/pubmed/25856312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123776
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