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S/T Phosphorylation of DLL1 Is Required for Full Ligand Activity In Vitro but Dispensable for DLL1 Function In Vivo during Embryonic Patterning and Marginal Zone B Cell Development

Interaction of Notch receptors with Delta- and Serrate-type ligands is an evolutionarily conserved mechanism that mediates direct communication between adjacent cells and thereby regulates multiple developmental processes. Posttranslational modifications of both receptors and ligands are pivotal for...

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Autors principals: Braune, Eike-Benjamin, Schuster-Gossler, Karin, Lyszkiewicz, Marcin, Serth, Katrin, Preusse, Kristina, Madlung, Johannes, Macek, Boris, Krueger, Andreas, Gossler, Achim
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993573/
https://ncbi.nlm.nih.gov/pubmed/24449764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00965-13
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