Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2

Notch signaling is a cellular pathway regulating cell-fate determination and adult tissue homeostasis. Little is known about how canonical Notch ligands or Fringe enzymes differentially affect NOTCH1 and NOTCH2. Using cell-based Notch signaling and ligand-binding assays, we evaluated differences in...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kakuda, Shinako, LoPilato, Rachel K., Ito, Atsuko, Haltiwanger, Robert S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586220/
https://ncbi.nlm.nih.gov/pubmed/32820046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014407
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