Nalaganje...

Deciphering the Fringe-mediated Notch Code: Identification of activating and inhibiting sites allowing discrimination between ligands

Fringe proteins are β3-N-acetylglucosaminyltransferases that modulate Notch activity by modifying O-fucose residues on Epidermal Growth Factor-like (EGF) repeats of Notch. Mammals have three Fringes: Lunatic, Manic, and Radical. While Lunatic and Manic Fringe inhibit Notch1 activation from Jagged1 a...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Dev Cell
Main Authors: Kakuda, Shinako, Haltiwanger, Robert S.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263050/
https://ncbi.nlm.nih.gov/pubmed/28089369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.12.013
Oznake: Označite
Brez oznak, prvi označite!