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Deciphering the Fringe-mediated Notch Code: Identification of activating and inhibiting sites allowing discrimination between ligands
Fringe proteins are β3-N-acetylglucosaminyltransferases that modulate Notch activity by modifying O-fucose residues on Epidermal Growth Factor-like (EGF) repeats of Notch. Mammals have three Fringes: Lunatic, Manic, and Radical. While Lunatic and Manic Fringe inhibit Notch1 activation from Jagged1 a...
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| Publicado no: | Dev Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5263050/ https://ncbi.nlm.nih.gov/pubmed/28089369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.12.013 |
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