Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration

Por Sabbadini, Roger A
Publicado em 2011

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway

Por Gu, Yapeng, Forostyan, Tetyana, Sabbadini, Roger, Rosenblatt, Jody
Publicado em 2011

Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P

Por Slattum, Gloria, Gu, Yapeng, Sabbadini, Roger, Rosenblatt, Jody
Publicado em 2013

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-β-stimulated collagen production by cardiac fibroblasts

Por Gellings Lowe, Nicole, Swaney, James S., Moreno, Kelli M., Sabbadini, Roger A.
Publicado em 2009

Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism

Por Finley, Amanda, Chen, Zhoumou, Esposito, Emanuela, Cuzzocrea, Salvatore, Sabbadini, Roger, Salvemini, Daniela
Publicado em 2013

Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody

Por Camaré, Caroline, Trayssac, Magali, Garmy-Susini, Barbara, Mucher, Elodie, Sabbadini, Roger, Salvayre, Robert, Negre-Salvayre, Anne
Publicado no Br J Pharmacol (2015)

The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen

Por Wojciak, Jonathan M., Zhu, Norman, Schuerenberg, Karen T., Moreno, Kelli, Shestowsky, William S., Hiraiwa, Masao, Sabbadini, Roger, Huxford, Tom
Publicado em 2009

Preclinical evaluation of VAX-IP, a novel bacterial minicell-based biopharmaceutical for nonmuscle invasive bladder cancer

Por Tsuji, Shingo, Chen, Xuguang, Hancock, Bryan, Hernandez, Veronica, Visentin, Barbara, Reil, Katherine, Sabbadini, Roger, Giacalone, Matthew, Godbey, WT
Publicado no Mol Ther Oncolytics (2016)

Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo

Por Weth, Daniela, Benetti, Camilla, Rauch, Caroline, Gstraunthaler, Gerhard, Schmidt, Helmut, Geisslinger, Gerd, Sabbadini, Roger, Proia, Richard L., Kress, Michaela
Publicado no Front Neurosci (2015)

Immunization with non-replicating E. coli minicells delivering both protein antigen and DNA protects mice from lethal challenge with lymphocytic choriomeningitis virus

Por Giacalone, Matthew J., Zapata, Juan C., Berkley, Neil L., Sabbadini, Roger A., Chu, Yen-Lin, Salvato, Maria S., McGuire, Kathleen L.
Publicado em 2006

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

Por Ponnusamy, Suriyan, Selvam, Shanmugam Panneer, Mehrotra, Shikhar, Kawamori, Toshihiko, Snider, Ashley J, Obeid, Lina M, Shao, Yuan, Sabbadini, Roger, Ogretmen, Besim
Publicado em 2012

Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer

Por Ader, Isabelle, Gstalder, Cécile, Bouquerel, Pierre, Golzio, Muriel, Andrieu, Guillaume, Zalvidea, Santiago, Richard, Sylvain, Sabbadini, Roger A., Malavaud, Bernard, Cuvillier, Olivier
Publicado no Oncotarget (2015)

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

Por Caballero, Sergio, Swaney, James, Moreno, Kelli, Afzal, Aqeela, Kielczewski, Jennifer, Stoller, Glenn, Cavalli, Amy, Garland, William, Hansen, Geneviève, Sabbadini, Roger, Grant, Maria B.
Publicado em 2008

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

Por Berdyshev, Evgeny V., Gorshkova, Irina, Usatyuk, Peter, Kalari, Satish, Zhao, Yutong, Pyne, Nigel J., Pyne, Susan, Sabbadini, Roger A., Garcia, Joe G. N., Natarajan, Viswanathan
Publicado em 2011

Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

Por Goldshmit, Yona, Matteo, Rosalia, Sztal, Tamar, Ellett, Felix, Frisca, Frisca, Moreno, Kelli, Crombie, Duncan, Lieschke, Graham J., Currie, Peter D., Sabbadini, Roger A., Pébay, Alice
Publicado em 2012

The S1P/S1PR2 axis regulates early airway T cell infiltration in murine mast cell-dependent acute allergic responses

Por Oskeritzian, Carole A., Hait, Nitai C., Wedman, Piper, Chumanevich, Alena, Kolawole, Elizabeth M., Price, Megan M., Falanga, Yves T., Harikumar, Kuzhuvelil B., Ryan, John J., Milstien, Sheldon, Sabbadini, Roger, Spiegel, Sarah
Publicado no J Allergy Clin Immunol (2014)

Anti-S1P antibody as a novel therapeutic strategy for VEGFR TKI resistant renal cancer

Por Zhang, Liang, Wang, Xiaoen, Bullock, Andrea J., Callea, Marcella, Shah, Harleen, Song, Jiaxi, Moreno, Kelli, Visentin, Barbara, Deutschman, Douglas, Alsop, David C., Atkins, Michael B., Mier, James W., Signoretti, Sabina, Bhasin, Manoj, Sabbadini, Roger A., Bhatt, Rupal S.
Publicado no Clin Cancer Res (2015)

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies1

Por O'Brien, Nicole, Jones, S. Tarran, Williams, David G., Cunningham, H. Brad, Moreno, Kelli, Visentin, Barbara, Gentile, Angela, Vekich, John, Shestowsky, William, Hiraiwa, Masao, Matteo, Rosalia, Cavalli, Amy, Grotjahn, Douglas, Grant, Maria, Hansen, Geneviève, Campbell, Mary-Ann, Sabbadini, Roger
Publicado em 2009

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Por Crack, Peter J, Zhang, Moses, Morganti-Kossmann, Maria Cristina, Morris, Andrew J, Wojciak, Jonathan M, Fleming, Jonathan K, Karve, Ila, Wright, David, Sashindranath, Maithili, Goldshmit, Yona, Conquest, Alison, Daglas, Maria, Johnston, Leigh A, Medcalf, Robert L, Sabbadini, Roger A, Pébay, Alice
Publicado em 2014

Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling

Por Cheng, Jin, Sahani, Sadhna, Hausrat, Torben Johann, Yang, Jenq-Wei, Ji, Haichao, Schmarowski, Nikolai, Endle, Heiko, Liu, Xinfeng, Li, Yunbo, Böttche, Rahel, Radyushkin, Konstantin, Maric, Hans M., Hoerder-Suabedissen, Anna, Molnár, Zoltán, Prouvot, Pierre-Hugues, Trimbuch, Thorsten, Ninnemann, Olaf, Huai, Jisen, Fan, Wei, Visentin, Barbara, Sabbadini, Roger, Strømgaard, Kristian, Stroh, Albrecht, Luhmann, Heiko J., Kneussel, Matthias, Nitsch, Robert, Vogt, Johannes
Publicado no Neuron (2016)