The S1P/S1PR2 axis regulates early airway T cell infiltration in murine mast cell-dependent acute allergic responses

BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid produced by mast cells (MC) upon cross-linking of their high affinity receptors for IgE by antigen (Ag) that can amplify MC responses by binding to its S1P receptors. Acute MC-dependent allergic reaction can lead to systemic shock...

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Опубликовано в: :J Allergy Clin Immunol
Главные авторы: Oskeritzian, Carole A., Hait, Nitai C., Wedman, Piper, Chumanevich, Alena, Kolawole, Elizabeth M., Price, Megan M., Falanga, Yves T., Harikumar, Kuzhuvelil B., Ryan, John J., Milstien, Sheldon, Sabbadini, Roger, Spiegel, Sarah
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388821/
https://ncbi.nlm.nih.gov/pubmed/25512083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.10.044
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