Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo

At the site of injury activated platelets release various mediators, one of which is sphingosine 1-phosphate (S1P). It was the aim of this study to explore whether activated human platelets had a pronociceptive effect in an in vivo mouse model and whether this effect was based on the release of S1P...

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Publicat a:Front Neurosci
Autors principals: Weth, Daniela, Benetti, Camilla, Rauch, Caroline, Gstraunthaler, Gerhard, Schmidt, Helmut, Geisslinger, Gerd, Sabbadini, Roger, Proia, Richard L., Kress, Michaela
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406086/
https://ncbi.nlm.nih.gov/pubmed/25954148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2015.00140
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