Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?

od Pyne, Nigel J., Pyne, Susan
Izdano 2011

Sphingosine kinase 2 and multiple myeloma

od Pyne, Nigel J., Pyne, Susan
izdano v Oncotarget (2017)

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

od Pyne, Nigel J., Pyne, Susan
izdano v Molecules (2017)

Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?

od Pyne, Nigel J., Pyne, Susan
izdano v Front Oncol (2018)

SPHINGOSINE KINASE INHIBITORS AND CANCER: SEEKING THE GOLDEN SWORD OF HERCULES

od Pyne, Susan, Bittman, Robert, Pyne, Nigel J.
Izdano 2011

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

od Pyne, Susan, Edwards, Joanne, Ohotski, Jan, Pyne, Nigel J.
Izdano 2012

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration

od Long, Jaclyn S., Yokoyama, Kazuaki, Tigyi, Gabor, Pyne, Nigel J., Pyne, Susan
Izdano 2006

Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

od Alderton, Forbes, Sambi, Balwinder, Tate, Rothwelle, Pyne, Nigel J, Pyne, Susan
Izdano 2001

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

od Lim, Keng Gat, Gray, Alexander I, Pyne, Susan, Pyne, Nigel J
Izdano 2012

(R)-FTY720 METHYL ETHER IS A SPECIFIC SPHINGOSINE KINASE 2 INHIBITOR: EFFECT ON SPHINGOSINE KINASE 2 EXPRESSION IN HEK 293 CELLS AND ACTIN REARRANGEMENT AND SURVIVAL OF MCF-7 BREAS...

od Lim, Keng Gat, Sun, Chaode, Bittman, Robert, Pyne, Nigel J., Pyne, Susan
Izdano 2011

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators

od Liu, Zheng, MacRitchie, Neil, Pyne, Susan, Pyne, Nigel J., Bittman, Robert
Izdano 2013

Crystal Structure of Sphingosine Kinase 1 with PF-543

od Wang, Jing, Knapp, Stefan, Pyne, Nigel J., Pyne, Susan, Elkins, Jonathan M.
izdano v ACS Med Chem Lett (2014)

Synthesis of selective inhibitors of sphingosine kinase 1

od Baek, Dong Jae, MacRitchie, Neil, Pyne, Nigel J., Pyne, Susan, Bittman, Robert
Izdano 2013

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial...

od Byun, Hoe-Sup, Pyne, Susan, MacRitchie, Neil, Pyne, Nigel J., Bittman, Robert
Izdano 2013

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androg...

od McNaughton, Melissa, Pitman, Melissa, Pitson, Stuart M., Pyne, Nigel J., Pyne, Susan
izdano v Oncotarget (2016)

The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids

od Ramachandran, Subramaniam, Chu, Uyen B., Mavlyutov, Timur A., Pal, Arindam, Pyne, Susan, Ruoho, Arnold E.
Izdano 2009

Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells

od Pyne, Nigel J., Waters, Catherine M., Long, Jaclyn S., Moughal, Noreen A., Tigyi, Gabor, Pyne, Susan
Izdano 2007

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

od Long, Jaclyn S., Fujiwara, Yuko, Edwards, Joanne, Tannahill, Claire L., Tigyi, Gabor, Pyne, Susan, Pyne, Nigel J.
Izdano 2010

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors: ENZYME INHIBITION KINETICS, ALLOSTERISM, PROTEASOMAL DEGRADATION, AND ACTIN REARRANGEMENT IN MCF-7 BREAST CANCER CELLS

od Lim, Keng G., Tonelli, Francesca, Li, Zaiguo, Lu, Xuequan, Bittman, Robert, Pyne, Susan, Pyne, Nigel J.
Izdano 2011

Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools

od Long, Jaclyn, Darroch, Peter, Wan, Kah Fei, Kong, Kok Choi, Ktistakis, Nicholas, Pyne, Nigel J., Pyne, Susan
Izdano 2005