Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?

Yazar: Pyne, Nigel J., Pyne, Susan
Baskı/Yayın Bilgisi 2011

Sphingosine kinase 2 and multiple myeloma

Yazar: Pyne, Nigel J., Pyne, Susan
Yayımlandı Oncotarget (2017)

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

Yazar: Pyne, Nigel J., Pyne, Susan
Yayımlandı Molecules (2017)

Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?

Yazar: Pyne, Nigel J., Pyne, Susan
Yayımlandı Front Oncol (2018)

SPHINGOSINE KINASE INHIBITORS AND CANCER: SEEKING THE GOLDEN SWORD OF HERCULES

Yazar: Pyne, Susan, Bittman, Robert, Pyne, Nigel J.
Baskı/Yayın Bilgisi 2011

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

Yazar: Pyne, Susan, Edwards, Joanne, Ohotski, Jan, Pyne, Nigel J.
Baskı/Yayın Bilgisi 2012

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration

Yazar: Long, Jaclyn S., Yokoyama, Kazuaki, Tigyi, Gabor, Pyne, Nigel J., Pyne, Susan
Baskı/Yayın Bilgisi 2006

Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

Yazar: Alderton, Forbes, Sambi, Balwinder, Tate, Rothwelle, Pyne, Nigel J, Pyne, Susan
Baskı/Yayın Bilgisi 2001

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

Yazar: Lim, Keng Gat, Gray, Alexander I, Pyne, Susan, Pyne, Nigel J
Baskı/Yayın Bilgisi 2012

(R)-FTY720 METHYL ETHER IS A SPECIFIC SPHINGOSINE KINASE 2 INHIBITOR: EFFECT ON SPHINGOSINE KINASE 2 EXPRESSION IN HEK 293 CELLS AND ACTIN REARRANGEMENT AND SURVIVAL OF MCF-7 BREAS...

Yazar: Lim, Keng Gat, Sun, Chaode, Bittman, Robert, Pyne, Nigel J., Pyne, Susan
Baskı/Yayın Bilgisi 2011

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators

Yazar: Liu, Zheng, MacRitchie, Neil, Pyne, Susan, Pyne, Nigel J., Bittman, Robert
Baskı/Yayın Bilgisi 2013

Crystal Structure of Sphingosine Kinase 1 with PF-543

Yazar: Wang, Jing, Knapp, Stefan, Pyne, Nigel J., Pyne, Susan, Elkins, Jonathan M.
Yayımlandı ACS Med Chem Lett (2014)

Synthesis of selective inhibitors of sphingosine kinase 1

Yazar: Baek, Dong Jae, MacRitchie, Neil, Pyne, Nigel J., Pyne, Susan, Bittman, Robert
Baskı/Yayın Bilgisi 2013

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial...

Yazar: Byun, Hoe-Sup, Pyne, Susan, MacRitchie, Neil, Pyne, Nigel J., Bittman, Robert
Baskı/Yayın Bilgisi 2013

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androg...

Yazar: McNaughton, Melissa, Pitman, Melissa, Pitson, Stuart M., Pyne, Nigel J., Pyne, Susan
Yayımlandı Oncotarget (2016)

The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids

Yazar: Ramachandran, Subramaniam, Chu, Uyen B., Mavlyutov, Timur A., Pal, Arindam, Pyne, Susan, Ruoho, Arnold E.
Baskı/Yayın Bilgisi 2009

Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells

Yazar: Pyne, Nigel J., Waters, Catherine M., Long, Jaclyn S., Moughal, Noreen A., Tigyi, Gabor, Pyne, Susan
Baskı/Yayın Bilgisi 2007

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

Yazar: Long, Jaclyn S., Fujiwara, Yuko, Edwards, Joanne, Tannahill, Claire L., Tigyi, Gabor, Pyne, Susan, Pyne, Nigel J.
Baskı/Yayın Bilgisi 2010

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors: ENZYME INHIBITION KINETICS, ALLOSTERISM, PROTEASOMAL DEGRADATION, AND ACTIN REARRANGEMENT IN MCF-7 BREAST CANCER CELLS

Yazar: Lim, Keng G., Tonelli, Francesca, Li, Zaiguo, Lu, Xuequan, Bittman, Robert, Pyne, Susan, Pyne, Nigel J.
Baskı/Yayın Bilgisi 2011

Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools

Yazar: Long, Jaclyn, Darroch, Peter, Wan, Kah Fei, Kong, Kok Choi, Ktistakis, Nicholas, Pyne, Nigel J., Pyne, Susan
Baskı/Yayın Bilgisi 2005