Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?

Por Pyne, Nigel J., Pyne, Susan
Publicado em 2011

Sphingosine kinase 2 and multiple myeloma

Por Pyne, Nigel J., Pyne, Susan
Publicado no Oncotarget (2017)

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

Por Pyne, Nigel J., Pyne, Susan
Publicado no Molecules (2017)

Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?

Por Pyne, Nigel J., Pyne, Susan
Publicado no Front Oncol (2018)

SPHINGOSINE KINASE INHIBITORS AND CANCER: SEEKING THE GOLDEN SWORD OF HERCULES

Por Pyne, Susan, Bittman, Robert, Pyne, Nigel J.
Publicado em 2011

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

Por Pyne, Susan, Edwards, Joanne, Ohotski, Jan, Pyne, Nigel J.
Publicado em 2012

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration

Por Long, Jaclyn S., Yokoyama, Kazuaki, Tigyi, Gabor, Pyne, Nigel J., Pyne, Susan
Publicado em 2006

Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

Por Alderton, Forbes, Sambi, Balwinder, Tate, Rothwelle, Pyne, Nigel J, Pyne, Susan
Publicado em 2001

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

Por Lim, Keng Gat, Gray, Alexander I, Pyne, Susan, Pyne, Nigel J
Publicado em 2012

(R)-FTY720 METHYL ETHER IS A SPECIFIC SPHINGOSINE KINASE 2 INHIBITOR: EFFECT ON SPHINGOSINE KINASE 2 EXPRESSION IN HEK 293 CELLS AND ACTIN REARRANGEMENT AND SURVIVAL OF MCF-7 BREAS...

Por Lim, Keng Gat, Sun, Chaode, Bittman, Robert, Pyne, Nigel J., Pyne, Susan
Publicado em 2011

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators

Por Liu, Zheng, MacRitchie, Neil, Pyne, Susan, Pyne, Nigel J., Bittman, Robert
Publicado em 2013

Crystal Structure of Sphingosine Kinase 1 with PF-543

Por Wang, Jing, Knapp, Stefan, Pyne, Nigel J., Pyne, Susan, Elkins, Jonathan M.
Publicado no ACS Med Chem Lett (2014)

Synthesis of selective inhibitors of sphingosine kinase 1

Por Baek, Dong Jae, MacRitchie, Neil, Pyne, Nigel J., Pyne, Susan, Bittman, Robert
Publicado em 2013

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial...

Por Byun, Hoe-Sup, Pyne, Susan, MacRitchie, Neil, Pyne, Nigel J., Bittman, Robert
Publicado em 2013

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androg...

Por McNaughton, Melissa, Pitman, Melissa, Pitson, Stuart M., Pyne, Nigel J., Pyne, Susan
Publicado no Oncotarget (2016)

The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids

Por Ramachandran, Subramaniam, Chu, Uyen B., Mavlyutov, Timur A., Pal, Arindam, Pyne, Susan, Ruoho, Arnold E.
Publicado em 2009

Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells

Por Pyne, Nigel J., Waters, Catherine M., Long, Jaclyn S., Moughal, Noreen A., Tigyi, Gabor, Pyne, Susan
Publicado em 2007

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

Por Long, Jaclyn S., Fujiwara, Yuko, Edwards, Joanne, Tannahill, Claire L., Tigyi, Gabor, Pyne, Susan, Pyne, Nigel J.
Publicado em 2010

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors: ENZYME INHIBITION KINETICS, ALLOSTERISM, PROTEASOMAL DEGRADATION, AND ACTIN REARRANGEMENT IN MCF-7 BREAST CANCER CELLS

Por Lim, Keng G., Tonelli, Francesca, Li, Zaiguo, Lu, Xuequan, Bittman, Robert, Pyne, Susan, Pyne, Nigel J.
Publicado em 2011

Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools

Por Long, Jaclyn, Darroch, Peter, Wan, Kah Fei, Kong, Kok Choi, Ktistakis, Nicholas, Pyne, Nigel J., Pyne, Susan
Publicado em 2005