Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

We demonstrate here that the bioactive lipid sphingosine 1-phosphate (S1P) uses sphingosine 1-phosphate receptor 4 (S1P(4)) and human epidermal growth factor receptor 2 (HER2) to stimulate the extracellular signal regulated protein kinase 1/2 (ERK-1/2) pathway in MDA-MB-453 cells. This was based on...

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Detalhes bibliográficos
Main Authors: Long, Jaclyn S., Fujiwara, Yuko, Edwards, Joanne, Tannahill, Claire L., Tigyi, Gabor, Pyne, Susan, Pyne, Nigel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975218/
https://ncbi.nlm.nih.gov/pubmed/20837468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.117945
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