The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

Sphingosine kinase 1 (SK1) is an enzyme that catalyzes the phosphorylation of sphingosine to produce the bioactive lipid sphingosine 1-phosphate (S1P). We demonstrate here that the SK1 inhibitor, SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of SK1 in huma...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Loveridge, Carolyn, Tonelli, Francesca, Leclercq, Tamara, Lim, Keng Gat, Long, Jaclyn S., Berdyshev, Evgeny, Tate, Rothwelle J., Natarajan, Viswanathan, Pitson, Stuart M., Pyne, Nigel J., Pyne, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998105/
https://ncbi.nlm.nih.gov/pubmed/20926375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127993
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados