The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

Sphingosine kinase 1 (SK1) is an enzyme that catalyzes the phosphorylation of sphingosine to produce the bioactive lipid sphingosine 1-phosphate (S1P). We demonstrate here that the SK1 inhibitor, SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of SK1 in huma...

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Bibliografske podrobnosti
Main Authors: Loveridge, Carolyn, Tonelli, Francesca, Leclercq, Tamara, Lim, Keng Gat, Long, Jaclyn S., Berdyshev, Evgeny, Tate, Rothwelle J., Natarajan, Viswanathan, Pitson, Stuart M., Pyne, Nigel J., Pyne, Susan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998105/
https://ncbi.nlm.nih.gov/pubmed/20926375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127993
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