The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

We have previously shown that treatment of androgen-sensitive LNCaP cells with the sphingosine kinase (SK) inhibitor SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of two N-terminal variants of SK1 (SK1a and SK1b), increases C22:0-ceramide and diadenosine 5...

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Detalhes bibliográficos
Main Authors: Tonelli, Francesca, Alossaimi, Manal, Natarajan, Viswanathan, Gorshkova, Irina, Berdyshev, Evgeny, Bittman, Robert, Watson, David G., Pyne, Susan, Pyne, Nigel J
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030851/
https://ncbi.nlm.nih.gov/pubmed/24970170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom3020316
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