Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

BACKGROUND: Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cells generate intracellular S1P, here we ha...

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Main Authors: Berdyshev, Evgeny V., Gorshkova, Irina, Usatyuk, Peter, Kalari, Satish, Zhao, Yutong, Pyne, Nigel J., Pyne, Susan, Sabbadini, Roger A., Garcia, Joe G. N., Natarajan, Viswanathan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031585/
https://ncbi.nlm.nih.gov/pubmed/21304987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016571
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