The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl) thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

BACKGROUND AND PURPOSE: Sphingosine kinase catalyses the formation of sphingosine 1-phosphate and is linked with androgen receptor signalling in prostate cancer cells. Therefore, we investigated the effect of sphingosine kinase inhibitors on androgen receptor expression. EXPERIMENTAL APPROACH: Andro...

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Detalhes bibliográficos
Main Authors: Tonelli, Francesca, Alossaimi, Manal, Williamson, Leon, Tate, Rothwelle J, Watson, David G, Chan, Edmond, Bittman, Robert, Pyne, Nigel J, Pyne, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596653/
https://ncbi.nlm.nih.gov/pubmed/23113536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12035
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