Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

Mechanisms by which cancer cells communicate with the host organism to regulate lung colonization/metastasis are unclear. We show that this communication occurs via sphingosine 1-phosphate (S1P) generated systemically by sphingosine kinase 1 (SK1), rather than via tumour-derived S1P. Modulation of s...

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Detalhes bibliográficos
Main Authors: Ponnusamy, Suriyan, Selvam, Shanmugam Panneer, Mehrotra, Shikhar, Kawamori, Toshihiko, Snider, Ashley J, Obeid, Lina M, Shao, Yuan, Sabbadini, Roger, Ogretmen, Besim
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494075/
https://ncbi.nlm.nih.gov/pubmed/22707406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200244
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